| Registro completo |
| Provedor de dados: |
Genet. Mol. Biol.
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| País: |
Brazil
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| Título: |
Identification and characterization of polymorphisms at the HSA alpha1-acid glycoprotein (ORM*) gene locus in Caucasians
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| Autores: |
Owczarek,Catherine M.
Owczarek,Aleksander L.
Board,Philip G.
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| Data: |
2002-01-01
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| Ano: |
2002
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| Palavras-chave: |
Human alpha1-acid glycoprotein
RFLP
Linkage disequilibrium
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| Resumo: |
Human alpha1-acid glycoprotein (AGP) or orosomucoid (ORM) is a major acute phase protein that is thought to play a crucial role in maintaining homeostasis. Human AGP is the product of a cluster of at least two adjacent genes located on HSA chromosome 9. Using a range of restriction endonucleases we have investigated DNA variation at the locus encoding the AGP genes in a panel of healthy Caucasians. Polymorphisms were identified using BamHI, EcoRI, BglII, PvuII, HindIII, TaqI and MspI. Non-random associations were found between the BamHI, EcoRI, BglII RFLPs. The RFLPs detected with PvuII, TaqI and MspI were all located in exon 6 of both AGP genes. The duplication of an AGP gene was observed in 11% of the indiviuals studied and was in linkage disequilibrium with the TaqI RFLP. The identification and characterization of these polymorphisms will prove useful for other population and forensic studies.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572002000100004
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| Editor: |
Sociedade Brasileira de Genética
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| Relação: |
10.1590/S1415-47572002000100004
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| Formato: |
text/html
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| Fonte: |
Genetics and Molecular Biology v.25 n.1 2002
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| Direitos: |
info:eu-repo/semantics/openAccess
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